Risk factors for acute fatty liver of pregnancy include first pregnancy, a male fetus, and multiple gestation.

Risk factors for acute fatty liver of pregnancy include first pregnancy, a male fetus, and multiple gestation.

• A. True
• B. False
• C. Only first pregnancy and female fetus
• D. Only twin gestation

Answer: (A)

AFLP tends to occur in pregnancies with higher metabolic stress and fetal metabolic factors. Being in a first pregnancy means the maternal liver is encountering late-pregnancy metabolic changes for the first time, which can increase susceptibility to hepatic lipidosis. Twin or multiple gestations amplify metabolic demand and placental load, raising the risk of fatty liver changes in the mother. The observation that a male fetus is associated with AFLP suggests a fetal contribution to the risk, possibly related to differences in fetal lipid metabolism, though the exact mechanism isn’t fully understood. With these factors all lining up with what’s been observed in AFLP cases, the statement is true.

AFLP tends to occur in pregnancies with higher metabolic stress and fetal metabolic factors. Being in a first pregnancy means the maternal liver is encountering late-pregnancy metabolic changes for the first time, which can increase susceptibility to hepatic lipidosis. Twin or multiple gestations amplify metabolic demand and placental load, raising the risk of fatty liver changes in the mother. The observation that a male fetus is associated with AFLP suggests a fetal contribution to the risk, possibly related to differences in fetal lipid metabolism, though the exact mechanism isn’t fully understood. With these factors all lining up with what’s been observed in AFLP cases, the statement is true.