In DIC treatment, replacement of which product is used to restore clotting factors?

In DIC treatment, replacement of which product is used to restore clotting factors?

• A. Fresh frozen plasma
• B. Platelets
• C. Cryoprecipitate
• D. Albumin

Answer: (A)

In DIC, the body uses up many clotting factors, causing a consumption coagulopathy that leads to bleeding. Replacing multiple coagulation factors quickly is best achieved with fresh frozen plasma, because it contains a broad range of factors II, V, VII, IX, X, XI, XII and other plasma proteins needed for proper clot formation. This helps correct the prolonged clotting times (PT and aPTT) and supports hemostasis during active bleeding. Cryoprecipitate, by contrast, mainly replenishes fibrinogen and certain other components like factor VIII and von Willebrand factor, and would be chosen if fibrinogen is notably low. Platelets address low platelet counts, while albumin isn’t used to restore clotting factors.

In DIC, the body uses up many clotting factors, causing a consumption coagulopathy that leads to bleeding. Replacing multiple coagulation factors quickly is best achieved with fresh frozen plasma, because it contains a broad range of factors II, V, VII, IX, X, XI, XII and other plasma proteins needed for proper clot formation. This helps correct the prolonged clotting times (PT and aPTT) and supports hemostasis during active bleeding.

Cryoprecipitate, by contrast, mainly replenishes fibrinogen and certain other components like factor VIII and von Willebrand factor, and would be chosen if fibrinogen is notably low. Platelets address low platelet counts, while albumin isn’t used to restore clotting factors.