Gestational hyperthyroidism tends to be more severe in pregnancies with which conditions?

Gestational hyperthyroidism tends to be more severe in pregnancies with which conditions?

• A. Hyperemesis gravidarum or multiple gestation
• B. Diabetes mellitus
• C. Placenta previa
• D. Preeclampsia

Answer: (A)

Gestational hyperthyroidism tends to be more severe when there are higher levels of human chorionic gonadotropin (hCG), because hCG can weakly stimulate the thyroid gland through the TSH receptor. Conditions that produce very high hCG—such as hyperemesis gravidarum and multiple gestation—lead to greater thyroid stimulation and more pronounced thyrotoxicosis. The other conditions listed do not inherently raise hCG to the same extent, so they are not typically associated with increased severity of gestational hyperthyroidism.

Gestational hyperthyroidism tends to be more severe when there are higher levels of human chorionic gonadotropin (hCG), because hCG can weakly stimulate the thyroid gland through the TSH receptor. Conditions that produce very high hCG—such as hyperemesis gravidarum and multiple gestation—lead to greater thyroid stimulation and more pronounced thyrotoxicosis. The other conditions listed do not inherently raise hCG to the same extent, so they are not typically associated with increased severity of gestational hyperthyroidism.