For antiphospholipid syndrome in pregnancy, what prophylaxis is recommended?

For antiphospholipid syndrome in pregnancy, what prophylaxis is recommended?

• A. Prophylactic heparin
• B. Warfarin throughout pregnancy
• C. Aspirin alone
• D. No prophylaxis

Answer: (A)

Antiphospholipid syndrome raises the risk of placental thrombi, which can cause miscarriage and growth problems. The most effective preventive measure in pregnancy is anticoagulation with heparin. Heparin helps reduce clot formation without crossing the placenta, making it safe for the fetus and effective at protecting placental circulation. Warfarin is avoided in pregnancy because it is teratogenic and can harm the fetus. Aspirin alone does not provide adequate protection against the thrombotic events APS can cause, though it may be used in some regimens as an adjunct. Therefore, prophylactic heparin is the recommended choice to prevent thrombotic complications in pregnancy with APS.

Antiphospholipid syndrome raises the risk of placental thrombi, which can cause miscarriage and growth problems. The most effective preventive measure in pregnancy is anticoagulation with heparin. Heparin helps reduce clot formation without crossing the placenta, making it safe for the fetus and effective at protecting placental circulation. Warfarin is avoided in pregnancy because it is teratogenic and can harm the fetus. Aspirin alone does not provide adequate protection against the thrombotic events APS can cause, though it may be used in some regimens as an adjunct. Therefore, prophylactic heparin is the recommended choice to prevent thrombotic complications in pregnancy with APS.