Fibrinogen level during pregnancy tends to?

Fibrinogen level during pregnancy tends to?

• A. Decrease
• B. Increase by about 50%
• C. Remain unchanged
• D. Initially decrease then increase

Answer: (B)

Fibrinogen levels rise during pregnancy as part of the body's shift toward a hypercoagulable state to protect against massive bleeding at delivery. The liver increases production of fibrinogen under hormonal influences, and levels typically climb by about 50% from nonpregnant values, peaking in the late third trimester. In practical terms, a normal nonpregnant range (roughly 200–400 mg/dL) can rise to around 300–600 mg/dL as pregnancy progresses. This increase aids hemostasis at delivery but also contributes to a higher risk of thromboembolism, which is why the trend is toward higher, not lower, levels as gestation advances.

Fibrinogen levels rise during pregnancy as part of the body's shift toward a hypercoagulable state to protect against massive bleeding at delivery. The liver increases production of fibrinogen under hormonal influences, and levels typically climb by about 50% from nonpregnant values, peaking in the late third trimester. In practical terms, a normal nonpregnant range (roughly 200–400 mg/dL) can rise to around 300–600 mg/dL as pregnancy progresses. This increase aids hemostasis at delivery but also contributes to a higher risk of thromboembolism, which is why the trend is toward higher, not lower, levels as gestation advances.