Antibiotics in pregnancy: which class is contraindicated due to teratogenic risk?

Antibiotics in pregnancy: which class is contraindicated due to teratogenic risk?

• A. Penicillins
• B. Tetracyclines
• C. Cephalosporins
• D. Macrolides

Answer: (B)

Tetracyclines are avoided in pregnancy because they cross the placenta and deposit in developing calcifying tissues, binding calcium in teeth and bones. This can cause permanent tooth discoloration and enamel hypoplasia in the fetus, and may interfere with bone growth. Because these effects are irreversible and well documented, tetracyclines are contraindicated during pregnancy. Other antibiotic classes listed—penicillins and cephalosporins—have long safety records in pregnancy and are typically preferred when an antibiotic is needed. Macrolides can be used if penicillins aren’t suitable, but are chosen with consideration of the situation.

Tetracyclines are avoided in pregnancy because they cross the placenta and deposit in developing calcifying tissues, binding calcium in teeth and bones. This can cause permanent tooth discoloration and enamel hypoplasia in the fetus, and may interfere with bone growth. Because these effects are irreversible and well documented, tetracyclines are contraindicated during pregnancy. Other antibiotic classes listed—penicillins and cephalosporins—have long safety records in pregnancy and are typically preferred when an antibiotic is needed. Macrolides can be used if penicillins aren’t suitable, but are chosen with consideration of the situation.